Table 2.
Summary of intrinsic membrane responses of in vitro recorded Im neurons belonging to group I, II and III based on cluster analysis
| Parameter | Group I (n = 11) | Group II (n = 5) | Group III (n = 11) |
|---|---|---|---|
| RMP (mV) | −68.2 ± 1.5 | −70.8 ± 2.5 | −77.8 ± 1.4 |
| III | III | I, II | |
| Rin (MΩ) | 562 ± 31 | 593 ± 50 | 777 ± 28 |
| III | III | I, II | |
| Membrane τ (ms) | 19.4 ± 0.9 | 25.0 ± 1.4 | 17.8 ± 1.1 |
| II | I, III | II | |
| AHP (mV) | −13.5 ± 1.0 | −12.7 ± 1.9 | −12.2 ± 0.7 |
| AP amplitude (mV) | 71.9 ± 1.7 | 82.1 ± 2.8 | 80.1 ± 1.3 |
| II, III | II | I | |
| AP width (ms) | 0.67 ± 0.04 | 1.0 ± 0.2 | 0.61 ± 0.03 |
| II | I, III | II | |
| Sag ratio | 0.86 ± 0.02 | 0.92 ± 0.01 | 0.89 ± 0.01 |
| Adaptation index | 0.59 ± 0.05 | 0.24 ± 0.08 | 0.78 ± 0.04 |
| II, III | I, III | I,II | |
| Max. firing (Hz) | 32.7 ± 1.9 III | 34.2 ± 5 | 43.3 ± 2.7 I |
All values are shown as mean ±s.e.m. Statistical differences between the three groups, estimated based on ANOVA with post hoc Bonferroni test, are indicated under the corresponding parameter, P < 0.05. Abbreviations: AHP, afterhyperpolarization; AP, action potential; Cm, membrane capacitance; Max. firing, maximal firing; RMP, resting membrane potential; Rin, input resistance.