Table 3.

All subjects—odds ratios for promoter hypermethylation (95% CI).

	Ever-smokers versus never-smokers	Age per 10 years	Female versus male	Upper versus lower lobe
Univariatea
APC	1.3 (0.6–2.9)	1.1 (0.9–1.4)	0.6 (0.5–0.8)	1.6 (0.9–2.7)
CCND2	6.9 (1.6–29.8)	1.9 (1.4–2.7)	0.8 (0.6–1.1)	2.3 (1.2–4.4)
Multivariatea
APC	1.0 (0.4–2.6)	1.0 (0.8–1.3)	0.6 (0.4–0.8)	1.6 (1.0–2.8)
CCND2	2.8 (0.6–12.1)	1.7 (1.2–2.4)	0.8 (0.6–1.2)	2.0 (1.0–3.8)

^aAssociations between clinical parameters and gene hypermethylation, assessed at PMR > 0%, in all 316 lung specimens from 151 subjects.