Table 2.

a. Echocardiographic characteristics with cytokine response to cardiac troponin I in patients with idiopathic dilated cardiomyopathy

	Normal IL-10 response (n = 22)	Heightened IL-10 response (n =13)
LVEF (%) (n=35)	23 ± 7	23 ± 6
LVEDd (cm) (n=34)	6.5 ± 1.0	6.3 ± 0.9
MV DT (mS) (n=30)	182 ± 48	238 ±74*
MV E/A (n=32)	1.4 ± 0.9	0.8 ± 0.3*
PV S (cm/s) (n=29)	46 ± 13	48 ± 12
PV S/D (n=29)	1.2 ± 0.4	1.3 ± 0.6

b. Univariable correlation analysis of echocardiographic findings with cytokine response to cardiac troponin I in patients with idiopathic dilated cardiomyopathy
	Correlation with Cytokine Responses to cTnI by ELISpot (Spearman’s r)
	IL-10 response	IFN-γ response	IL-10/IFN-γ response
LVEF (%)	-0.03	- 0.12	0.01
LVEDd (cm)	0.11	- 0.03	0.06
MV DT (mS)	0.37*	0.12	0.14
MV E/A	- 0.56*	0.15	-0.64*
PV S (cm/s)	0.01	- 0.56*	0.55*
PV S/D	0.15	- 0.54*	0.61*

Values are mean ± standard deviation unless otherwise stated.

^*p value < 0.05 when comparing normal and heightened IL -10 response groups.

Abbreviations: IL-10 – interleukin 10, LVEF – left ventricular ejection fraction, LVEDd – left ventricular end diastolic diameter, MV DT – mitral valve deceleration time, MV E/A – ratio of mitral valve inflow peak E (early diastolic) and A (late diastolic) velocities, PV S– pulmonary venous peak systolic velocity, PV S/D – ratio of pulmonary venous peak systolic (S) velocity to peak anterograde diastolic (D) velocities.

Abbreviations: ELISpot - enzyme-linked immunospot assay, IL-10 – interleukin 10, IFN-γ – interferon-gamma, LVEF – left ventricular ejection fraction, LVEDd – left ventricular end diastolic diameter, MV DT – mitral valve deceleration time, MV E/A – ratio of mitral valve inflow peak E (early diastolic) and A (late diastolic) velocities, PV S– pulmonary venous peak systolic velocity, PV S/D – ratio of pulmonary venous peak systolic (S) velocity to peak anterograde diastolic (D) velocities. cTnI – cardiac troponin I.

^*p value < 0.05