Table 5.
Kinase | % control | Kinase | % control |
---|---|---|---|
mTOR | 4.6 | CSF1R | 2.4 |
CSNK1E | 2.7 | MKNK2 | 0.9 |
PIK3C2G | 3.5 | PIK3CA | 0.55 |
PIK3CA(C420R) | 0.1 | PIK3CA(E542K) | 0.25 |
PIK3CA(E545K) | 0.25 | PIK3CA(H1047L) | 0 |
PIK3CA(H1047Y)) | 1.4 | PIK3CA(I800L) | 0 |
PIK3CA(M1043I) | 1 | PIK3CA(Q546K) | 0.35 |
PIK3CG | 0.2 | PIK4CB | 1.7 |
Compound 3 was profiled at a concentration of 1 μM against a diverse panel of 442 kinases by Ambit Biosciences