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. Author manuscript; available in PMC: 2011 May 10.
Published in final edited form as: Int J Radiat Oncol Biol Phys. 2009 Oct 1;75(2):534–542. doi: 10.1016/j.ijrobp.2009.06.034

Figure 3. Inhibition of radiation-induced NF-κB activation by curcumin.

Figure 3

Curcumin inhibited radiation-induced activation of NF-κB. (a) HCT116 cells were incubated with curcumin (25 μM) for 4 h, exposed to radiation (10 Gy) and nuclear extracts prepared at indicated time points post IR were probed for NF-κB. Consistent suppression of radiation-induced NF-κB activity was noted at all time points (b-d). Suppression of radiation-induced NF-κB was also observed in HCT116 (b), HT29 (c) and SW620 (d) cells at both 10 and 25 μM concentrations, with a greater response observed for higher doses curcumin.