Table 3.

Gene Ontology—Biological Process classification groupings overrepresented in A) Male versus female subjects, and B) Female, Over versus Under 55 years old (P ≤ 0.01, group size ≥ 5). Included are raw P values, odds ratio of group overrepresentation, expected (Exp. Count) versus actual (Count) number of significant genes, and total genes (Size) in the enriched categories. Biological processes that are labeled as “sub-processes” of a Functional Category are indented underneath the Category.

A) All male versus female subjects
Gene Ontology ID	P	Odds Ratio	Exp. Count	Count	Size	GO: Biological Process Functional Category Description
GO:0006811	4.50E-04	1.473	76	103	563	ion transport
GO:0006812	1.26E-04	1.663	49	73	361	cation transport
GO:0015672	7.71E-03	2.126	31	57	233	monovalent inorganic cation transport
GO:0030001	1.81E-02	1.690	40	61	297	metal ion transport
GO:0006814	6.86E-03	2.577	12	25	88	sodium ion transport
GO:0006813	7.10E-04	1.798	15	25	115	potassium ion transport
GO:0006821	3.71E-05	2.582	6	12	42	chloride transport
GO:0050877	1.23E-03	1.346	81	102	598	neurological process
GO:0007600	3.98E-03	1.626	47	70	352	sensory perception
GO:0007606	5.71E-03	3.321	9	23	68	sensory perception of chemical stimulus
GO:0007608	3.55E-04	2.975	7	17	54	sensory perception of smell
GO:0050909	4.21E-04	5.524	2	6	13	sensory perception of taste
GO:0007601	3.67E-03	1.719	23	36	172	visual perception
GO:0007186	4.50E-04	1.496	73	100	540	G-protein coupled receptor protein signaling pathway
GO:0007565	2.02E-06	2.843	8	18	59	female pregnancy
GO:0042430	1.26E-04	12.877	1	4	6	indole and derivative metabolic process

B) Female, over versus under 55 years old
Gene Ontology ID	P	Odds Ratio	Exp. Count	Count	Size	Functional Category Description
GO:0042770	7.00E-03	8.498	0	3	38	DNA damage response, signal transduction