Biosynthetic steps of JA and JA-mediated secondary metabolites of which proteins silenced by RNAi in this study are highlighted. In bold font are the proteins that were silenced by RNAi in isogenic lines of N. attenuata plants that were planted into a field plantation in the plant’s native habitat in the Great Basin Desert, where T. mucorea could freely oviposit on the plants. OPDA, 12-oxo-phytodienoic acid; ACS, acyl-coenzyme A synthetase; HPL, hydroperoxide lyase; JAR, JA resistant; JA-Ile, JA-Ile conjugate.