Skip to main content
. 2011 Mar 4;286(18):15652–15665. doi: 10.1074/jbc.M110.201087

FIGURE 7.

FIGURE 7.

Activation of the AMPK and suppression of the SAPK/JNK signaling pathway by CTRP13. A, time course of AMPK activation in 3T3-L1 adipocytes induced by recombinant CTRP13 (5 μg/ml). AMPK-P, AMPKα phosphorylated at Thr-172. B, time course of AMPK activation in L6 myotubes induced by CTRP13 (5 μg/ml). C, time course of AMPK activation in clone 9 liver cells induced by CTRP13 (5 μg/ml). D, suppression of SAPK/JNK stress signaling (phosphorylation at Thr-183/Tyr-185) by CTRP13 (5 μg/ml) in control (BSA) or palmitate (300 μm)-treated H4IIE hepatocytes. H4IIE cells were treated with or without palmitate in 2% free fatty acid-free BSA in the absence or presence of CTRP13 for 5 h. E, enhanced insulin signaling (Akt phosphorylation at Thr-308) by CTRP13 in palmitate (300 μm)-treated H4IIE hepatocytes in response to insulin (10 nm). All data are expressed as -fold change (normalized to control) and as mean ± S.E. (error bars) (n = 3 in all experiments). *, p < 0.05; **, p < 0.01; #, p < 0.001.