FIGURE 1.
Effects of Lqh-dprIT3 on the BgNav1-1 sodium channel. A, sodium current traces in the absence (left) and presence (right) of Lqh-dprIT3 (300 nm). To measure the effect of Lqh-dprIT3, the following protocol was used: a 20-Hz train of 50 5-ms depolarizing prepulses to 50 mV as the conditional pulses, followed by a series of 20-ms depolarizing test pulses between −80 and −65 mV. The holding potential was −120 mV. B and C, current-voltage relations in the absence (●) and presence of 100 nm (△ and ◁) or 300 nm (□) Lqh-dprIT3 with (B) and without (C) the conditional depolarizing pulses. D, conductance-voltage relations in the absence (●) and the presence of 100 nm (△) or 300 nm (□) Lqh-dprIT3 with the conditional depolarizing pulses. The voltage dependence of activation was measured using the protocol described under “Experimental Procedures.”