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Substitutions of Leu-1285 with other residues does not alter the hypersensitivity of BgNav1-1 to Lqh-dprIT3. Shown are conductance curves in the absence (●) and presence (○) of 300 nm Lqh-dprIT3 for four BgNav1-1a channel mutants with different side chain substitutions at position 1285. The conductance-voltage relation was measured using the protocol described under “Experimental Procedures.”
