TABLE 2.

Voltage dependence of activation of BgNa_v1-1a and mutants before and after the application of 300 nm Lqh-dprIT₃

Each value represents the mean ± S.D. for at least five oocytes.

	Toxin-free		Lqh-dprIT3 (300 nm)
	V0.5	k	V0.5	k1	A1	V0.5	k2	A2
					%			%
BgNav1-1a	−28.4 ± 2.1	4.1 ± 0.6	−28.1 ± 1.5	5.0 ± 0.3	82 ± 5	−60.0 ± 3.3	10.4 ± 1.6	18 ± 5
R502G	−28.3 ± 0.6	4.0 ± 0.2	−27.5 ± 1.3	5.1 ± 0.1	86 ± 2	−60.0 ± 3.5	11.6 ± 1.5	14 ± 2
L1285P	−25.0 ± 1.0	5.4 ± 0.2	−25.1 ± 1.6	5.5 ± 0.5	29 ± 4a	−64.3 ± 1.5	8.6 ± 0.9	71 ± 4a
V1685A	−27.5 ± 0.7	3.9 ± 0.2	−26.0 ± 1.5	4.7 ± 0.3	86 ± 4	−61.3 ± 2.0	7.4 ± 1.0	14 ± 4
I1806L	−26.2 ± 0.5	4.4 ± 0.3	−24.6 ± 1.2	5.1 ± 0.2	87 ± 3	−63.5 ± 2.0	6.6 ± 0.8	13 ± 3

^a Significant differences from BgNa_v1-1a (p < 0.05).