TABLE 3.

Voltage dependence of activation of BgNa_v1-1a and L1285 substitutions before and after the application of 300 nm Lqh-dprIT₃

Each value represents the mean ± S.D. for at least five oocytes.

	Toxin-free		Lqh-dprIT3 (300 nm)
	V0.5	k	V0.5	k1	A1	V0.5	k2	A2
					%			%
BgNav1-1a	−28.4 ± 2.1	4.1 ± 0.6	−28.1 ± 1.5	5.0 ± 0.3	82 ± 5	−60.0 ± 3.3	10.4 ± 1.6	18 ± 5
L1285P	−25.0 ± 1.0	5.4 ± 0.2	−25.1 ± 1.6	5.5 ± 0.5	29 ± 4a	−64.3 ± 1.5	8.6 ± 0.9	71 ± 4a
L1285F	−28.6 ± 1.1	4.2 ± 0.2	−25.0 ± 1.0	4.8 ± 0.2	87 ± 4	−61.6 ± 3.1	8.3 ± 0.2	13 ± 4
L1285G	−28.7 ± 0.8	3.9 ± 0.3	−27.8 ± 1.2	4.0 ± 0.6	85 ± 3	−50.6 ± 6	10.1 ± 2.0	15 ± 3
L1285K	−30.5 ± 2.1	4.6 ± 0.4	−27.5 ± 1.5	5.9 ± 0.6	86 ± 2	−67.2 ± 1.9	8.5 ± 1.2	14 ± 2
L1285C	−28.7 ± 0.3	4.1 ± 0.3	−25.9 ± 1.6	4.6 ± 0.2	85 ± 2	−59.6 ± 3.1	11.0 ± 1.6	15 ± 2

^a Significant differences from BgNa_v1-1a (p < 0.05).