TABLE 5.

Voltage dependence of activation of BgNa_v1-1a and mutants before and after the application of 300 nm Lqh-dprIT₃

Each value represents the mean + S.D. for at least five oocytes.

	Toxin-free		Lqh-dprIT3 (300 nm)
	V0.5	k	V0.5	k1	A1	V0.5	k2	A2
					%			%
BgNav1-1a	−28.4 ± 2.1	4.1 ± 0.6	−28.1 ± 1.5	5.0 ± 0.3	82 ± 5	−60.0 ± 3.3	10.4 ± 1.6	18 ± 5
K1E	−35.5 ± 2.5	4.7 ± 0.4	−35.8 ± 3.9	4.8 ± 0.3	82 ± 4	−70.0 ± 6.1	10.7 ± 2.1	18 ± 4
R2E	−34.3 ± 2.8	5.1 ± 0.3	−32.9 ± 2.1	5.5 ± 0.4	81 ± 4	−75.5 ± 4.5	7.4 ± 0.8	19 ± 4
R3E	−34.2 ± 2.5	5.0 ± 0.2	−34.7 ± 2.7	6.8 ± 0.3	75 ± 5	−76.1 ± 8.7	7.0 ± 0.6	25 ± 5
R4E	−33.7 ± 3.8	5.7 ± 0.5	−26.9 ± 3.6	8.1 ± 0.6	43 ± 8a	−87.9 ± 3.6	5.1 ± 0.5	57 ± 8a
R5E	−24.0 ± 1.9	7.2 ± 0.4	−25.0 ± 3.9	8.6 ± 0.8	35 ± 7a	−63.6 ± 5.0	7.9 ± 0.6	65 ± 7a

^a Significant differences from BgNa_v1-1a (p < 0.05).