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A, current model for filovirus entry and how this process could be inhibited by an endosome-targeted C-peptide. CatL, cathepsin L; CatB, cathepsin B; rbs, receptor-binding site. B, sequence alignment of GP NHR and CHR segments from EboV, MarV, and ASLV. residues that differ from EboV are shown in gray. C, six-helix bundle structure of the EboV GP2 ectodomain (Protein Data Bank code 2EBO) reported by Malashkevich et al. (22).
