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CHIP disrupts the Smad1-Smad4 complex but not the Smad2-Smad4 complex. A, CHIP disrupts Smad1-Smad4 complex. The wild type CHIP protein or its missense mutants was mixed with the pre-formed complexes of pseudophosphorylated Smad1 and Smad4, and the mixture was analyzed by size exclusion chromatography. B, CHIP fails to disrupt Smad2-Smad4 complex. Gel filtration assay was performed for the mixture of wild type CHIP and the preformed complex of Smad2-MH2(DMD) and Smad4-L-MH2.
