FIGURE 4.

Effect of complement depletion with CVF on PEG-8-induced C9 deposition and CNV size. Intraperitoneal treatment with CVF significantly reduced total complement activity in mouse serum compared with PBS-treated animals (A). C9 deposition (red; B, C, and H) and CNV size (D, E, and I) were significantly reduced in CVF-treated animals. Negative controls with no primary antibodies are also shown (F and G). *, p < 0.05 compared with the PBS-treated group. i.p., intraperitoneal. Scale bar = 100 μm.