TABLE 1.
Ten most prominently regulated canonical pathways in response to fasting
MIF, macrophage migration inhibitory factor; GPCR, G protein-coupled receptor; APC, adenomatosis polyposis coli; SCF, stem cell factor; WNT, Wnt (wingless-related MMTV integration site) protein superfamily.
| Pathway | P value | Objects |
|
|---|---|---|---|
| Changed | Out of | ||
| Intestine | |||
| Immune response; antigen presentation by MHC class I | 8.06E-06 | 10 | 26 |
| Cytoskeleton remodeling; regulation of actin cytoskeleton by Rho GTPases | 1.55E-04 | 8 | 23 |
| Immune response; CCR3 signaling in eosinophils | 1.06E-03 | 12 | 59 |
| Immune response; MIF, the neuroendocrine-macrophage connector | 1.48E-03 | 8 | 31 |
| Blood coagulation; GPCRs in platelet aggregation | 1.69E-03 | 11 | 54 |
| Cell cycle; role of APC in cell cycle regulation | 1.85E-03 | 8 | 32 |
| Cholesterol biosynthesis | 3.36E-03 | 6 | 21 |
| Cell cycle; the metaphase checkpoint | 4.10E-03 | 8 | 36 |
| Oxidative stress; role of ASK1 under oxidative stress | 4.34E-03 | 6 | 22 |
| Cell cycle; role of SCF complex in cell cycle regulation | 4.40E-03 | 7 | 29 |
| Kidney | |||
| Peroxisomal branched chain fatty acid oxidation | 1.63E-06 | 12 | 22 |
| Vitamin E (α-tocopherol) metabolism | 5.04E-06 | 10 | 17 |
| Peroxisomal straight-chain fatty acid β-oxidation | 2.99E-05 | 7 | 10 |
| Triacylglycerol metabolism | 3.03E-04 | 11 | 29 |
| Translation; regulation of translation initiation | 3.46E-04 | 10 | 25 |
| Cholesterol biosynthesis | 3.73E-04 | 9 | 21 |
| Mitochondrial long chain fatty acid β-oxidation | 5.95E-04 | 8 | 18 |
| Bile acid biosynthesis | 1.36E-03 | 10 | 29 |
| Immune response; MIF, the neuroendocrine-macrophage connector | 2.40E-03 | 10 | 31 |
| Polyamine metabolism | 2.81E-03 | 8 | 22 |
| Liver | |||
| Cholesterol biosynthesis | 5.53E-06 | 13 | 21 |
| Peroxisomal branched chain fatty acid oxidation | 1.14E-05 | 13 | 22 |
| Lipoprotein metabolism I; chylomicron, VLDL and LDL | 2.98E-05 | 7 | 8 |
| Lipoprotein metabolism II; HDL metabolism | 2.98E-05 | 7 | 8 |
| Translation; regulation of translation initiation | 7.16E-05 | 13 | 25 |
| Androstenedione and testosterone biosynthesis and metabolism | 7.24E-05 | 11 | 19 |
| Triacylglycerol metabolism | 1.08E-04 | 14 | 29 |
| Estrone metabolism | 1.11E-04 | 9 | 14 |
| Vitamin E (α-tocopherol) metabolism | 1.31E-04 | 10 | 17 |
| Aspartate and asparagine metabolism | 2.42E-04 | 11 | 21 |
| Muscle | |||
| Cytoskeleton remodeling | 1.01E-06 | 42 | 96 |
| Cytoskeleton remodeling; TGF, WNT, and cytoskeletal remodeling | 1.11E-05 | 43 | 107 |
| Immune response; antigen presentation by MHC class I | 1.35E-05 | 16 | 26 |
| Immune response; oncostatin M signaling via MAPK | 1.72E-05 | 20 | 37 |
| Neurodisease; Parkin disorder under Parkinson disease | 1.80E-05 | 17 | 29 |
| Proteolysis; role of Parkin in the ubiquitin-proteasomal pathway | 1.09E-04 | 14 | 24 |
| G-protein signaling; Ras family GTPases in kinase cascades | 1.09E-04 | 14 | 24 |
| Cell adhesion; chemokines and adhesion | 1.44E-04 | 36 | 93 |
| Transcription; Transcription regulation of amino acid metabolism | 1.99E-04 | 14 | 25 |
| Cytoskeleton remodeling; role of PKA in cytoskeleton reorganization | 2.49E-04 | 16 | 31 |