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. 2011 Mar 18;286(18):16504–16515. doi: 10.1074/jbc.M110.208447

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© 2011 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 7. — Effects of MB on rotenone-induced nigrostriatal dopaminergic neurodegeneration. Coronal brain sections from control (Veh/Sal), rotenone-treated (ROT/Sal), and rotenone/MB-treated (ROT/MB) rats were immunostained for TH (left) and ubiquitin (right). TH immunohistochemistry was shown at low magnification and high magnification in the SNC region. Dopaminergic denervation, cell body shrinkage, and neuronal loss were clearly observed in the ROT/Sal group, and all were improved in the MB treatment group. Dopaminergic fibers were sparse in VTA in the ROT/Sal group and improved in the ROT/MB group. Neurons with positive ubiquitin immunostaining were observed only in the ROT/Sal group. Scale bars, 200 μm.