FIGURE 9.

MB reduces cerebral ischemia reperfusion damage induced by transient focal cerebral ischemia. A, ischemia/reperfusion injury, induced by 1 h of middle cerebral artery occlusion and 24 h of reperfusion, inhibits mitochondrial complex activities (I, III, I-III, and IV). B, ischemic lesion depicted by triphenyltetrazolium chloride staining (white area) in the representative brain sections from control-treated (top) and MB-treated (bottom) rats at 24 h after ischemic stroke. C, quantification of ischemic lesion volume with vehicle or MB treatment. All data are represented as mean ± S.E. *, p < 0.05; **, p < 0.01; ***, p < 0.001.