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Transfer energies and tilt angles of S4-helix immersed in the lipid bilayer. A. Energies (diamonds) and tilt angles (open circles) calculated for different hydrophobic thicknesses of the bilayer for transmembrane (colored blue) and peripheral (colored purple) orientations of the S4 helix. ΔGcalc does not include the penalty for hydrophobic mismatch. B. Alternative orientations in the lipid bilayer of S4 peptide.
