Table 1.

Comparison of high-level features across models.

Model feature	FHCRC	MISCAN	UMICH
Implementation	simulation	simulation	analytic
Disease states	(2 stages) × (2 grades)	(3 × 2 stages) × (3 grades)	(2 stages) × (2 grades)
	local-regional, distant stage	T0 T3 local, distant stage	local-regional, distant stage
	low-moderate, high grade	low, moderate, high grade	low-moderate, high grade
Progression depends on	current PSA level	current disease state	delay time and mode of detection
Stage progression	yes	yes	yes
Grade progression	no	yes	yes
PSA test sensitivity*	output of model	endogenous parameter	endogenous parameter
Biopsy compliance†	estimated from PLCO	combined with PSA sensitivity	combined with PSA sensitivity
Biopsy sensitivity‡	based on literature review	combined with PSA sensitivity	combined with PSA sensitivity

^*Pr(PSA positive|Disease)

^†Pr(Biopsy received|PSA positive, Disease)

^‡Pr(Biopsy positive | Biopsy received, Disease)