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. 2009 Nov 6;10(11):R124. doi: 10.1186/gb-2009-10-11-r124

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Copyright ©2009 Marques et al.; licensee BioMed Central Ltd.

This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Substitution rates of ncRNA and protein-coding genes. The cumulative distributions of substitution rate for (a) exons and (b) promoters as measured for macroRNAs (red), lincRNAs (black) and protein-coding genes (blue). MacroRNA and lincRNA exons exhibit similar degrees of constraint and appear to evolve faster than protein-coding exons. Protein-coding gene promoters evolve under stronger constraint than ncRNA exons. MacroRNA promoters have lower substitution rates than lincRNA promoters.