Table 4.

FK506 kinetics (i.v.) in beagle dogs before and after bile duct ligation

Dog No.	Disposition rate constant (hr⁻¹)		Half-life (hr)		Clearance (ml/min)
	Pre.	Post.	Pre.	Post.	Pre.	Post.
1	0.1115	0.0550	6.2	13.5	315	251
2	0.1166	0.0530	6.0	13.1	366	313
3	0.1312	0.0860	5.3	8.1	296	347
4	0.0400	0.0644	17.3	10.8	253	400
6	0.0858	0.0586	8.1	11.8	368	249
Mean	0.10	0.06	8.6	11.5	320	312
SD	±0.04	±0.01	±5.0	±2.2	±49	±65
P	NS		NS		NS