Table 5.
Oral FK506 kinetics in mongrel dogs before and after bile duct ligation
| Dog No. | Disposition rate constant (hr−1) |
Half-life (hr) |
Maximum plasma concentration (ng/ml) |
Time to reach maximum plasma concentration (hr) |
Bioavail-ability (%) |
|||||
|---|---|---|---|---|---|---|---|---|---|---|
| Pre. | Post. | Pre. | Post. | Pre. | Post. | Pre. | Post. | Pre. | Post | |
| 1 | 0.096 | 0.042 | 7.2 | 16.5 | 1.9 | 4.0 | 2 | 4 | 9 | 56 |
| 3 | 0.120 | 0.096 | 5.8 | 7.2 | 2.3 | 11.3 | 1 | 2 | 9 | 42 |
| 4 | 0.123 | 0.066 | 5.6 | 10.4 | 2.8 | 3.2 | 1 | 4 | — | 21 |
| 5 | 0.088 | 0.087 | 7.9 | 8.0 | 4.9 | 1.8 | 1 | 3 | 12 | 23 |
| 6 | 0.114 | 0.084 | 6.1 | 8.2 | 2.5 | 3.1 | 2 | 6 | 5 | 60 |
| Mean | 0.114 | 0.075a | 6.5 | 10.1a | 2.9 | 4.7 | 1.4 | 3.8a | 9 | 40a |
| SD | ±0.002 | ±0.021 | 0.9 | 3.8 | ±1.2 | ±3.8 | ±0.55 | ±1.55 | ±3 | ±16 |
a
Significantly different from Pre. values (P<0.05).