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Effect of biliary diversion and bile salt supplementation on FK506 oral absorption
| Peak concentration (ng/ml) | Time to peak (hr) | (AUC) (mg/ml/hr) | Half-life (hr) | |
|---|---|---|---|---|
| Control | 10.9±7.5 | 1.1±0.9 | 44.4±38.1 | 8.9±1.7 |
| Control and bile salt | 11.9±10.9 | 0.9±0.2 | 36.4±25.9 | 8.7±2.1 |
| Biliary diversion | 5.4±3.1 | 2.3±1.0a | 33.3±20.0 | 9.8±1.8 |
| Biliary diversion and bile salt | 7.2±3.5 | 2.2±1.0a | 38.6±26.2 | 9.7±1.5 |
Significantly different from the control animals (P<0.05).
