Table 1.
Factors Associated with Appropriate CRC Surveillance for LS (N=181) [1]
| Categories | All High-Risk Subjects (N=181) | Appropriate Surveillance (N = 132) | Inappropriate Surveillance (N = 49) | |
|---|---|---|---|---|
| Frequency Row % | Frequency Row % | Frequency Row% | p-value [2] | |
| Demographics | ||||
| Mean Age | 46.52 [18–79] | 45.73 (+11.8) | 48.65 (+13.8) | 0.16 |
| Less than 40 years old | 51(28) | 38(75) | 13(25) | 0.07 |
| 40–49 years old | 49(27) | 41(84) | 8(16) | |
| 50 years old and above | 80(44) | 52(65) | 28(35) | |
| Unknown/Missing | 1(--) | 1-- | ||
| Gender | ||||
| Male | 59(33) | 42(71) | 17(29) | 0.72 |
| Female | 122(67) | 90(74) | 32(26) | |
| Educational Level | ||||
| Less than college | 55(31) | 41(75) | 14(25) | 0.86 |
| At least college graduate | 124(69) | 90(73) | 34(27) | |
| Unknown/Missing | 2(--) | 1-- | 1-- | |
| Income | ||||
| Less than $50,000 | 39(23) | 29(74) | 10(26) | 1.00 |
| $50,000 or greater | 129(77) | 96(74) | 33(26) | |
| Unknown/Missing | 13(--) | 7-- | 6-- | |
| Health Insurance | ||||
| Yes | 173(96) | 125(72) | 48(28) | 0.69 |
| No | 8(4) | 7(88) | 1(12) | |
| Personal History | ||||
| Cancer Status | 0.003 | |||
| Have had cancer | 100(55) | 82(82) | 18(18) | |
| Have not had cancer | 81(45) | 50(62) | 31(38) | |
| Colorectal Cancer | ||||
| Have had CRC | 75(41) | 64(85) | 11(15) | 0.002 |
| Have not had CRC | 106(59) | 68(64) | 38(36) | |
| Adenomas | ||||
| Have had adenomas | 33(18) | 28(85) | 5(15) | 0.13 |
| Have not had adenomas | 148(82) | 104(70) | 44(30) | |
| Perceived Colon Cancer Risk | 0.06 | |||
| Higher than average risk | 145(81) | 111(77) | 34(23) | |
| Average or low risk | 35(19) | 21(60) | 14(40) | |
| Unknown/Missing | 1(--) | -- -- | 1(--) | |
| Perceived Lifetime Colon Cancer Risk | ||||
| Mean (+/− SD) | 65.48 (+/− 28.0) | 66.54 (+28.6) | 62.71 (+26.7) | 0.42 |
| Family History | ||||
| Amsterdam Criteria | ||||
| Yes | 154(85) | 111(72) | 43(28) | 0.64 |
| No | 27(15) | 21(78) | 6(22) | |
| First Degree Relative (FDR) with CRC at <50 years old | ||||
| Yes | 101(56) | 79(78) | 22(22) | 0.09 |
| No | 80(44) | 53(66) | 27(34) | |
| Mean No. of FDR with CRC | 1.21 (+/− 0.96) | 1.23 (+0.9) | 1.16 (+1.1) | 0.66 |
| MMR Mutation in the Family | ||||
| Yes | 103(57) | 85(83) | 18(17) | 0.001 |
| No | 78(43) | 47(60) | 31(40) | |
| Health Practices | ||||
| Physician Visits (in 12 months) | ||||
| Never | 7(4) | 5(71) | 2(29) | 0.01 |
| 1–6 visits | 129(71) | 87(67) | 42(33) | |
| 7 or more visits | 45(25) | 40(89) | 5(11) | |
| Provider Primarily Responsible for Health Care | ||||
| Primary Care Provider | 145(82) | 100(69) | 45(31) | <0.01 |
| Specialist Provider | 24(13) | 24(100) | 0(0) | |
| Other or None | 9(5) | 6(67) | 3(33) | |
| Unknown/Missing | 3(--) | 2-- | 1-- | |
| Cancer prevention setting | ||||
| Private doctor’s office | 62(35) | 44(71) | 18(29) | 0.99 |
| HMO | 19(11) | 14(74) | 5(26) | |
| Community hospital | 20(11) | 15(75) | 5(25) | |
| Academic hospital | 48(27) | 36(75) | 12(25) | |
| Cancer center | 23(13) | 18(78) | 5(22) | |
| Other | 4(2) | 3(75) | 1(25) | |
| Unknown/Missing | 5(--) | 2-- | 3-- | |
| Academic or cancer center | 71(39) | 54(76) | 17(24) | 0.50 |
| Other | 110(61) | 78(71) | 32(29) | |
| Participation with Cancer Screening Tests | ||||
| Fully compliant with age-appropriate health screening | 153(85) | 109(71) | 44(29) | 0.35 |
| Partially compliant with age-appropriate screening recommendations | 28(15) | 23(82) | 5(18) | |
| Genetic Risk Assessment | ||||
| Physician Discussed Cancer Risk | ||||
| Yes | 144(80) | 110(76) | 34(24) | 0.06 |
| No | 37(20) | 22(60) | 15(40) | |
| Visited High-Risk Clinic | ||||
| Yes | 136(76) | 109(80) | 27(20) | <0.001 |
| No | 43(24) | 22(51) | 21(49) | |
| Unknown/Missing | 2(--) | 1-- | 1-- | |
| Genetic Testing Status | ||||
| Had genetic testing | 131(72) | 110(84) | 21(16) | <0.001 |
| No genetic testing | 50(28) | 22(44) | 28(56) | |
| Genetic Test Result | ||||
| Positive | 105(80) | 89(85) | 16(15) | 0.57 |
| Indeterminate | 26(20) | 21(81) | 5(19) | |
| True Negative | ---- | ---- | ---- | |
| Unknown | ---- | ---- | ---- | |
| Study Site | 0.34 | |||
| DFCI | 76(42) | 50(66) | 26(34) | |
| UM | 35(19) | 27(77) | 8(23) | |
| UCSF | 62(34) | 49(79) | 13(21) | |
| MGH | 8(4) | 6(75) | 2(25) | |
[1]
Includes study subjects who have part or all of their colon intact, and fullfilled at least one of the following:
a
positive personal genetic result
b
Amsterdam criteria and indeterminate genetic test result
c
Amsterdam criteria and no genetic testing done
d
No personal genetic testing, but with an identified mutation in the family
[2]
Fisher’s exact test was used for categorical variables, and T-test was used for continuous variables