Table 3.

Persistent perinatal CMD and infant development

	Persistent perinatal CMD		Categories of increasing exposure to perinatal CMD¥
	$\widehat{\beta }$(95% Confidence Interval)
Bayley sub-scale	SRQ ≥ 6 in pregnancy or 2 months postnatal§	SRQ ≥ 6 in pregnancy & 2 months postnatal§	Test-for-trend Χ2 (df); p-value
Cognitive
Crude	-0.99 (-2.12, 0.15)	-1.59 (-3.99, 0.82)	6.66(1); p < 0.025
Fully adjusted*	-0.64 (-1.79, 0.51)	-2.11 (-4.87, 0.65)	2.58(1); p > 0.10
Motor
Crude	-0.80 (-2.24, 0.65)	-4.19 (-8.60, 0.21)	13.08(1); p < 0.001
Fully adjusted*	0.15 (-1.52, 1.82)	-4.15 (-9.19, 0.89)	2.83(1); p > 0.05
Language
Crude	-0.16 (-1.45, 1.13)	-0.72 (-3.29, 1.85)	3.93(1); p < 0.05
Fully adjusted*	0.21 (-1.11, 1.53)	-1.12 (-4.42, 2.17)	0.23(1); p > 0.50
	Persistent postnatal CMD		Categories of increasing exposure to postnatal CMD¶
	$\widehat{\beta }$ (95% Confidence Interval)
Bayley sub-scale	SRQ ≥ 6 at postnatal 2 OR 12 months±	SRQ ≥ 6 at postnatal 2 & 12 months±	Test-for-trend Χ2 (df); p-value
Cognitive
Crude	0.61 (-1.28, 2.51)	-0.25 (-1.49, 0.99)	0.04(1); p > 0.50
Fully adjusted*	0.90 (-1.13, 2.93)	0.20 (-1.28, 1.67)	0.29(1); p > 0.50
Motor
Crude	-2.22 (-5.96, 1.52)	-3.01 (-8.01, 2.00)	3.37(1); p > 0.10
Fully adjusted*	-1.42 (-4.91, 2.07)	-2.65 (-9.26, 3.96)	1.75(1); p > 0.10
Language
Crude	2.16 (0.35, 3.96)	-0.61 (-3.66, 2.44)	0.60(1); p > 0.25
Fully adjusted*	2.37 (0.18, 4.55)	-0.56 (-4.01, 2.90)	0.74(1); p > 0.25

Exploratory analyses showing association between persistent maternal common mental disorder (CMD) and infant Bayley scale scores at 12 months of age (n = 183 in adjusted model)

^§ Reference category = SRQ < 6 in pregnancy and 2 months postnatal. ^± Reference category = SRQ < 6 at 2 and 12 months postnatal. *Adjusted for all potential confounders. ^¥No CMD, CMD in pregnancy or postnatal (2 months), CMD in both pregnancy and postnatal. ^¶No CMD, CMD in pregnancy or postnatal (12 months), CMD in both pregnancy and postnatal.