Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Comparison of different models for TCR triggering
| Model | Requirements/restraints imposed (+) or not (−) by a model | |||
| Ligand multivalency | Relative interreceptor orientation in TCR oligomers | Duration of ligand-MIRR contact/lifetime of TCR oligomers | Ligand affinity/avidity | |
| Kinetic proofreading | − | − | + | + |
| Serial triggering | − | − | + | + |
| Serial encounter | − | − | + | + |
| Conformational | − | − | + | + |
| Permissive geometry | + | + | − | − |
| Clustering | + | − | − | + |
| Segregation | − | − | + | + |
| Mechanosensor | − | − | + | + |
| SCHOOL | + | + | + | + |
