Figure 4.

Putative DENV-associated Ae. aegypti protein interaction sub-networks. One major and five minor sub-networks include virus-associated mosquito proteins inferred from RNAi screen (blue), physical interaction assay (green) and microarray study (yellow), and proteins that connect to at least three of the above proteins (black). Functional analysis of these proteins in the major sub-network highlighted four regions consisting of highly interconnected proteins with closely related functions in each of replication/transcription/translation (RTT), immunity, transport and metabolism. Other regions are comprised of proteins with diverse or unknown functions. Proteins included in the RTT region are listed in Additional file 7.