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. 2010 Jul 22;11:449. doi: 10.1186/1471-2164-11-449

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Copyright ©2010 Belda et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Pontetial metabolic complementation between W. glossinidia and S. glossinidius at thiamine biosynthesis level. Thiazole phosphate carboxylate (THZ-P) is synthesized by S. glossinidius from exogenous thiamin through salvage pathway (tenA2, thiM), whereas hydroxymethyl pyrimidine pyrophosphate (HMP-PP) is synthesized by W. glossinidia from 5-aminoimidazole ribonucleotide (AIR) (thiC, thiD). THZ-P and HMP-PP are shared between both bacteria to produce the functional thiamine diphosphate that is provided to the tsetse host.