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. 2010 Sep 29;11:530. doi: 10.1186/1471-2164-11-530

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Copyright ©2010 Martianov et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Correlative analysis of CREB and CREM binding site occupancy. A. Association of CREB, pol II and H3K4me3 in GC1-spg cells. Comparison of pol II and H3K4me3 tag density in the region of +/- 5 kb around the CREB-occupied loci. Clustering analysis identifies 3 classes, A; CREB loci with low or no pol II and H3K4me3, B-C; CREB loci with high pol II and H3K4me3 corresponding to transcription on the sense and anti-sense strands, respectively. B. Comparison of CREM tag density in the region of +/- 5 kb around the CREB-occupied loci. Clustering identifies 2 groups A; CREB loci with low or no CREM and B; CREB loci with high CREM. C. Venn diagramme comparing common and cell-specific CREB/CREM occupancy of binding sites using the CREB data in panel B and the equivalent analysis of the CREM occupied loci (data not shown).