Figure 3.

Gene Ontology enrichment analysis of genes regulated in zebrafish gill by zinc depletion. The closest human homologue to each regulated zebrafish gene at each time point was submitted to the online DAVID functional annotation classification tool and significantly overrepresented GO terms and other semantic descriptors were extracted and presented as clusters based on interrelationships between terms calculated by the tool. Probability for enrichment of each category is given in numerals for the entire data set (all genes from all time points). Levels of probability for enrichment at discrete time points are indicated by the heat-map.