Table 3.
Transcription factors regulated (>1.8-fold and FDR = 0.1) by zinc depletion for 8 hours to 14 days.
| Time point | Unigene ID | Gene Description | Human homologuea | Fold Changeb |
|---|---|---|---|---|
| 8 h | Dr.15390 | Forkhead box L1 (foxl1) | FOXL1 | 3.59 |
| Dr.77946 | Wu:fc07d06 (wu:fc07d06) | POU2F1 | 3.01 | |
| Dr.77235 | Iroquois homeobox protein 1, b (irx1b) | IRX1 | 2.94 | |
| Dr.34224 | Si:ch211-272f15.2 (si:ch211-272f15.2) | CRSP3 | 2.13 | |
| Dr.107820 | Hepatocyte nuclear factor 4, alpha (hnf4a) | HNF4A | 1.90 | |
| Dr.75801 | Neurogenic differentiation (neurod) | NEUROD1 | -1.96 | |
| 1d | Dr.78408 | Friend leukemia integration 1a (fli1a) | FLI1 | 2.68 |
| Dr.15390 | Forkhead box L1 (foxl1) | FOXL1 | 2.42 | |
| Dr.77786 | Hypothetical protein LOC100005466 (LOC100005466) | ZNF235 | 1.82 | |
| Dr.158 | Distal-less homeobox gene 4a (dlx4a) | DLX6 | -2.23 | |
| Dr.77265 | Core promoter element binding protein (copeb) | KLF6 | -1.83 | |
| Dr.32618 | Homeo box A3a (hoxa3a) | HOX3A | -1.82 | |
| 4d | Dr.15418 | Hypothetical protein LOC792149 (wu:fc23f06) | TCF2 | -2.62 |
| Dr.53400 | Nuclear receptor subfamily 5, group A, member 1a (nr5a1a) | NR5A2 | -2.53 | |
| Dr.75880 | Zgc:112073 (zgc:112073) | HMGB3 | -2.25 | |
| Dr.76424 | Enhancer of zeste homolog 2 (Drosophila) (ezh2) | EZH2 | -2.21 | |
| Dr.77670 | RING1 and YY1 binding protein (rybp) | RYBP | -2.04 | |
| Dr.76824 | Interleukin enhancer binding factor 2 (ilf2) | ILF2 | -2.04 | |
| Dr.105034 | Zgc:153397 (cbx3) | CBX3 | -1.92 | |
| Dr.78440 | General transcription factor IIA, 1 (gtf2a1) | GTF2A1 | -1.82 | |
| Dr.83118 | Similar to hypoxia-inducible factor 2 alpha (LOC566886) | EPAS1 | -1.82 | |
| 7d | Dr.105034 | Zgc:153397 (zgc:153397) | CBX3 | 1.97 |
| Dr.82318 | NK2 homeobox 1a (nkx2.1a) | NKX2-4 | 1.88 | |
| Dr.30382 | Estrogen-related receptor alpha-like (esrral) | ESRRA | 1.80 | |
| Dr.429 | Distal-less homeobox gene 5a (dlx5a) | DLX5 | -2.63 | |
| Dr.132864 | Wilms tumor 1a (wt1a) | WT1 | -1.99 | |
| Dr.78812 | Hypothetical LOC568537 (LOC568537) | ZNF214 | -1.95 | |
| Dr.23936 | Si:rp71-1g18.1 (si:rp71-1g18.1) | ZKSCAN5 | -1.89 | |
| Dr.118285 | Similar to PHD finger protein 12 (LOC560119) | PHF12 | -1.84 | |
| Dr.75753 | Notch homolog 1a (notch1a) | NOTCH1 | -1.83 | |
| Dr.116189 | Hypothetical LOC573287 (LOC573287) | ZNF131 | -1.81 | |
| 14d | Dr.78812 | Hypothetical LOC568537 (LOC568537) | ZNF214 | -1.83 |
aThe closest human homologue with sequence similarity higher than 45% are listed.
b Positive numbers indicate up-regulation and negative numbers represent down-regulation