Table 2.
B. azoricus genes putatively involved in immune response and inflammatory reactions.
| Function | Gene Ontology n° | Gene Ontology description |
|---|---|---|
| Recognition | ||
| Peptidoglycan Recognition protein (PGRP) | GO: 0008745 | N-acetylmuramoyl-L-alanine amidase activity |
| Chitin binding protein | GO:0008061; GO:0006030 | Chitin binding; chitin metabolic process |
| Galectin 4-like protein | GO:0005529 | Sugar binding |
| Rhamnose-binding lectin | GO:0005529 | Sugar binding |
| Thrombospondin-like glycoprotein | GO:0007155; GO:0033627 | Cell adhesion; cell adhesion mediated by integrin |
| Glycoside hydrolase, Chitinase-like | GO:0005975 | Carbohydrate metabolic process |
| Mannose-6-phosphate receptor | GO:0005537 | Mannose binding |
| Contactin associated protein 2 | GO:0007155; GO:0005515 | Cell adhesion; protein binding |
| Tissue inhibitor of metalloproteinase | GO:0008191; GO:0005578 | Metalloendopeptidase inhibitor activity; proteinaceous extracellular matrix |
| Serpin (serine protease inhibitor) | GO:0004867 | Serine-type endopeptidase inhibitor activity |
| α2-Macroblobulin (thioester-containing protein) | GO:0004866 | Endopeptidase inhibitor activity |
| Syndecan binding protein | GO:0007265; GO:0005137 | Ras protein signal transduction; interleukin-5 receptor binding |
| Fibrinogen (pattern recognition receptor) | GO:0007165; GO:0005102 | signal transduction; receptor binding |
| Ficolin (opsonin, contain fibrinogen and collagen-like domains) | GO:0007165;GO:0005102 GO:0008228 | signal transduction; receptor binding; opsonization |
| Scavenger receptor cysteine-rich protein (SRCR) | GO:0005044 | Scavenger receptor activity |
| LBP/BPI (LPS binding, Crassostrea homologue) | GO:0008289 | Lipid binding |
| Signaling | ||
| Toll-interleukin receptor | GO:0045087; GO:0007165 | Innate immune response; signal transduction |
| Myd88 | GO:0004888 | Transmembrane receptor activity |
| TRAF (TNF receptor-associated factor) | GO:0007165; GO:0042981 | Signal transduction; regulation of apoptosis |
| IRAK | GO:0019221; GO:0051092 | Cytokine-mediated signaling pathway; regulation of NF-κB |
| MAPK | GO:0004672; GO:0006468 | Protein kinase activity; protein amino acid phosphorylation |
| p38 | GO:0004672; GO:0051403 | Protein kinase activity; stress-activated MAPK cascade |
| Notch homologue | GO:0007411; GO: 0007219 | Axon guidance; Notch signaling pathway |
| EGF receptor | GO:0007173; GO:0007165 | Epidermal growth factor receptor signaling Pathway; signal transduction |
| TNF receptor | GO:0007165; GO:0042981 | Signal transduction; regulation of apoptosis |
| Fibropellin homologue | GO:0005509; GO:0005515 | Calcium ion binding; protein binding |
| Laminin_EGF | GO:0005539 | Glycosaminoglycan binding |
| Cadherin (EGF domain containing) | GO:0016020; GO:0007156 | Membrane;homophilic cell adhesion |
| Integrin (fibronectin receptor) | GO:0007155; GO:0007229 | Cell adhesion; integrin mediated signaling pathway |
| Transcription | ||
| Nuclear Factor κB inhibitor | IPR015681 (InterPro) | Regulation of NF-κB activity |
| STAT | GO:0004871; GO:0045449 | Signal transducer activity; regulation of transcription |
| SH2 motif(Src homology 2 | GO:0007165; GO:0018108 | Signal transduction; peptidyl-tyrosine phosphorylation |
| P53 | GO:0006915; GO:0034984 | Apoptosis; cellular response to DNA damage stimulus |
| AP-1 (Proto-oncogene c-jun) | GO:0003700; GO:0045449 | Transcription factor activity; regulation of transcription |
| Tal (Crassostrea homologue) | GO:0045449; GO:0030528 | Regulation of transcription; transcription regulator activity |
| Effector and modulator molecules | ||
| Defensin (big defensin) | GO:0006952 | Defense response |
| Cytolysin | GO:0009404 | Toxin metabolic process |
| Apolipoprotein (plasminogen) | GO:0007596; GO:0004252 | Blood coagulation; serine-type endopeptidase activity |
| TNF (LPS-induced, α factor) | GO:0006955; GO:0006952 | Immune response; defense response |
| Interferon | GO:0042742 | Defense response to bacterium; regulation of innate immune response |
| TGF | GO:0006954; GO:0006917 | Inflammatory response; induction of apoptosis |
| Glutatione peroxidase | GO:0004602; GO:0006979 | Glutathione peroxidase activity; response to oxidative stress |
| Prostaglandin synthase/cyclooxygenase | GO:0006979; GO:0004601 | Response to oxidative stress; peroxidase activity |
| Fibronectin | GO:0001968 | Fibronectin binding |
| Metalloproteinase | GO:0004222; GO:0005578 | Metalloendopeptidase activity; proteinaceous extracellular matrix |
| Metallothionein | GO:0046872 | Metal ion binding |
| Ferritin | GO:0006879 | Cellular iron ion homeostasis |
| Tenascin | GO:0009611; GO:0007155 | Cell adhesion; response to wounding |
| Glucose-regulated protein 94 | GO:0006950 | Response to stress |