Table 1.

P-DUDES gene expression in cancer and cancer models

gene	direction	tissue	mechanism proposed	reference
CCDC80	DOWN	rat epithelial cells neoplastically transformed by β-catenin.		[9]
CCDC80	DOWN	thyroid neoplastic cell lines and tissues		[14]
CCDC80	DOWN	colon and pancreatic cancer cells.	mediates growth inhibition	[9]
SRPX	DOWN	highly malignant human pulmonary neuroendocrine tumors.		[10]
SRPX	DOWN	prostate carcinomas.		[89]
SRPX	DOWN	colorectal neoplasms.		[90]
SRPX	DOWN	lung adenocarcinomas.		[91]
SRPX	DOWN	colon adenocarcinomas.		[92]
SRPX	DOWN	endothelial cells, myeloma		[93]
SRPX	DOWN	stromal fibroblast cells from liver metastases of colorectal cancer		[94]
SRPX	NA	SRPX knock-out mouse embryonic fibroblasts	involvement in the maturation process of autophagy	[13]
SRPX	NA	malignant tumors including lymphomas, lung adenocarcinomas and hepatomas	Tumors appear in SRPX-knock out mice	[11]
SRPX	NA	human cancer cell lines.	apoptosis induction in human cancer cell lines; both the P-DUDES and the sushi regions necessary	[12]
SRPX2	NA	endothelial cells	mediator of angiogenesis	[20]
SRPX2	NA		ligand for uPAR	[19]
SRPX2	UP	gastric cancer	enhancing cellular migration and adhesion through FAK signaling	[16,17]
SRPX2	UP	pro-B leukemia cells		[5]