Table 3.

Similarity between known thioredoxins and the novel Thx-fold families

Pfam domain	Top PDB hit (PDB ID)	p-value	Top Scop hit	p-value	Top Pfam hit	p-value	Comment
ArsD	3ktb_A Arsenical resistance operon trans-acting repressor	0	d1iloa c.47.1.1	8.7E-10	pfam00462 Glutaredoxin	9.2E-07	Structure known, 3ktb, has Thx fold, as seen by Fatcat and Vast
DUF929	1fo5_A Thioredoxin	0.00015	d1fo5a c.47.1.1	0.00021	PF00085 Thioredoxin	0.00026
DUF1094	3fhk_A YphP disulfide isomerase	0	d1f9ma c.47.1.1	8.8E-06	pfam09085 Adhes-Ig_like pfam00085 Thioredoxin	1.3E-05 0.00035	Structure known, 3fhk, has Thx fold as stated by the authors
DUF1223	2axo_A Hypothetical protein	0	d2axoa1 c.47.1.19	0	pfam00462 Glutaredoxin	7.5E-08	Structure known, 2axo, classified as Thx in Scop
DUF1462	1xg8_A Hypothetical protein	0	d1xg8a c.47.1.17	0	pfam05768 DUF836 Glutaredoxin-like	1.5E-05	Structure known, 1xg8, classified as Thx in Scop
DUF2703	1ilo_A Conserved hypothetical protein	8.6E-06	d1iloa c.47.1.1	1.7E-05	PF03135 CagE_TrbE_VirB pfam00462 Glutaredoxin	0.00024 0.00061
DUF2847	3iv4_A Putative oxidoreductase	0	d1ep7a c.47.1.1	1.8E-10	pfam00085 Thioredoxin	2.1E-08	Structure known, 3iv4, has Thx fold, as stated by the authors
DUF3088	3ir4_A Glutaredoxin 2	1.6E-06	d1k0ma2 c.47.1.5	1.6E-06	PF02798 GST_N	0.00012
TrbC_Ftype	1dby_A Chloroplast thioredoxin	6.7E-07	d1dbya c.47.1.1	5.8E-07	PF00085 Thioredoxin	4.1E-06

Similarity scores (HHPred) supporting similarity between thioredoxins

and the nine novel Thx-fold families ArsD, DUF929, DUF1094, DUF1223, DUF1462, DUF2703, DUF2847, DUF3088 and TrbC_Ftype.