Figure 5.

Phylogenetic tree of the TNF superfamily. This phylogenetic tree of the TNF superfamily was produced by neighbor-joining of multiple sequence alignment of TNF superfamily sequences from insect and the homologous sequences of the TNFSF from higher animals [including Homo sapiens, Rattus norvegicus, Monodelphis domestica, Oncorhynchus mykiss, Salmo salar and Xenopus (Silurana) tropicalis]. Because the silkworm TNFSF homologs were produced by alignment with TNFSF5 and TNFSF13, the TNFSF sequences used in this phylogenetic tree were the TNFSF5 and TNFSF13 in different species. The TNFSF members predicted in Bombyx mori are marked with large red dots. The protein names use an abbreviation of species and gene names. The full species names are listed in the black frame on the right.