Table 2.
Up-regulation of genes in iBMDCs treated with [BF/S+L/Ep] for (A) 4 h or (B) 12 h compared to DMSO alone
| Gene Name | Accession Number | Expression Ratioa (+)/(-) | |
|---|---|---|---|
| At 4 h: | |||
| Cluster 1 | Adhesion molecules, Cytoskeleton, Cell movement | ||
| Ncam2 | neural cell adhesion molecule 2 | NM_010954 | 6.57 |
| Serpinb2 | serine (or cysteine) peptidase inhibitor, clade B, member 2 | NM_011111 | 4.50 |
| Ikbkg | inhibitor of kappa B kinase gamma | NM_010547 | 2.03 |
| Cluster 2 | Immune response | ||
| Amot | angiomotin | NM_153319 | 2.48 |
| Cxcl5 | chemokine (C-X-C motif) ligand 5 | NM_009141 | 8.63 |
| Irg1 | immunoresponsive gene 1 | XM_127883 | 2.17 |
| Cxcl7 | chemokine (C-X-C motif) ligand 7 | NM_023785 | 2.08 |
| Cluster 3 | Signal transmission, Transporter | ||
| Nrxn1 | neurexin I | Q9CS84 | 9.62 |
| Sorbs1 | sorbin and SH3 domain containing 1 | NM_009166 | 3.70 |
| Ahrr | aryl-hydrocarbon receptor repressor | NM_009644 | 2.37 |
| Abce1 | ATP-binding cassette, sub-family E (OABP), member 1 | NM_015751 | 2.10 |
| Cluster 4 | Cell cycle, DNA repair, Apoptosis | ||
| Cyr61 | cysteine rich protein 61 | NM_010516 | 6.60 |
| Mtap9 | microtubule-associated protein 9 | Q3TRR0 | 2.64 |
| Cluster 5 | Enzyme, Kinase | ||
| Ppfia1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF) | XM_133979 | 2.74 |
| Cluster 6 | DNA binding protein, Transcription factor | ||
| Wdhd1 | WD-repeat HMG-box DNA binding protein 1 | NM_172598 | 2.04 |
| Cluster 7 | Miscellaneous | ||
| Prdm10 | PR domain containing 10 | Q3UTQ7 | 6.98 |
| Tdrd3 | Tudor domain containing 3 | NM_172605 | 3.48 |
| Mif4gd | MIF4G domain containing | NM_027162 | 2.16 |
| Dnahc2 | dynein, axonemal, heavy chain 2 | O08826 | 2.09 |
| At 12 h: | |||
| Cluster 1 | Adhesion molecules, Cytoskeleton, Cell movement | ||
| Serpinb2 | serine (or cysteine) peptidase inhibitor, clade B, member 2 | NM_011111 | 3.34 |
| Cspg2 | chondroitin sulfate proteoglycan 2 | NM_019389 | 2.20 |
| Mmp8 | matrix metallopeptidase 8 | NM_008611 | 2.18 |
| Myo1d | Myosin ID | NM_177390 | 2.07 |
| Cluster 2 | Signal transmission, Transporter | ||
| Phip | pleckstrin homology domain interacting protein | Q32NY1 | 3.28 |
| Cd38 | CD38 antigen | NM_007646 | 2.51 |
| Rbp1 | retinol binding protein 1, cellular | NM_011254 | 2.28 |
| Ap3s2 | adaptor-related protein complex 3, sigma 2 subunit | NM_009682 | 2.12 |
| Golph4 | golgi phosphoprotein 4 | NM_175193 | 2.03 |
| Cluster 3 | Enzyme, Kinase | ||
| Dnm1l | dynamin 1-like | NM_152816 | 13.11 |
| Wdfy3 | WD repeat and FYVE domain containing 3 | NM_172882 | 4.64 |
| Acpp | acid phosphatase, prostate | NM_019807 | 2.18 |
| Apc | adenomatosis polyposis coli | NM_007462 | 2.15 |
| Adhfe1 | alcohol dehydrogenase, iron containing, 1 | NM_175236 | 2.04 |
| Cluster 4 | Immune response | ||
| Ctla4 | cytotoxic T-lymphocyte-associated protein 4 | NM_009843 | 11.16 |
| Cxcl7 | chemokine (C-X-C motif) ligand 7 | NM_023785 | 2.77 |
| Cluster 5 | RNA binding protein, Translation factor | ||
| Mrps5 | mitochondrial ribosomal protein S5 | NM_029963 | 2.20 |
| Sf4 | splicing factor 4 | NM_027481 | 2.45 |
| Cluster 6 | DNA binding protein, Transcription factor | ||
| Asb2 | ankyrin repeat and SOCS box-containing protein 2 | NM_023049 | 2.75 |
| Cluster 7 | Miscellaneous | ||
| Dnahc2 | dynein, axonemal, heavy chain 2 | O08826 | 3.11 |
| Ccdc89 | coiled-coil domain containing 89 | Q9DA73 | 2.01 |
a Expression ratio is defined as relative difference in expression with (+) compared to without (-) treatment with [BF/S+L/Ep] plant extract; (-) is DMSO vehicle control.