Table 3.
Top 10 fold-changing genes from each temporal cluster following infestation with P. ovis
| Cluster ID | Gene Symbol | Gene Description | Fold Change* |
|---|---|---|---|
| Cluster 1 | TMEM123 | Transmembrane protein 123 | 19.3 |
| CD83 | CD83 molecule | 9.1 | |
| ATF3 | Activating transcription factor 3 | 7.5 | |
| CYR61 | Cysteine-rich, angiogenic inducer, 61 | 5.4 | |
| BTG2 | BTG family, member 2 | 5.3 | |
| EGR1 | early growth response 1 | 4.5 | |
| CYR61 (2×) | cysteine-rich, angiogenic inducer, 61 | 4.5 | |
| GPR171 | G protein-coupled receptor 171 | 4.4 | |
| GADD45B | growth arrest and DNA-damage-inducible, beta | 4.1 | |
| Cluster 2 | IL6 | Interleukin-6 | 771.7 |
| CCL2 | Chemokine (C-C motif) ligand 2 | 35.7 | |
| CXCL2 | Chemokine (C-X-C motif) ligand 2 | 22.7 | |
| Unknown | N/A | 19.1 | |
| SELP (2×) | Selectin P (granule membrane protein 140 kDa, antigen CD62) | 17.2 to 18.1 | |
| SOCS3 | Suppressor of cytokine signalling 3 | 18.0 | |
| CSF3 | colony stimulating factor 3 (granulocyte) | 17.6 | |
| PDE4B | phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog, Drosophila) | 17.1 | |
| TNFAIP6 | tumor necrosis factor, alpha-induced protein 6 | 16.7 | |
| Cluster 3 | PTX3 (2×) | Pentraxin 3 | 225.6 to 317.2 |
| MMP1 (2×) | Matrix metallopeptidase 1 (interstitial collagenase) | 237.1 to 302.8 | |
| CXCL5 | Chemokine (C-X-C motif) ligand 5 | 218.0 | |
| SDS | Serine dehydratase | 134.3 | |
| MT1E | Metallothionein 1E | 76.9 | |
| PLEK | pleckstrin | 48.8 | |
| MS4A8B | membrane-spanning 4-domains, subfamily A, member 8B | 45.2 | |
| SOD2 | superoxide dismutase 2, mitochondrial | 31.5 | |
| Cluster 4 | IL8 (2×) | Interleukin-8 | 291.7 to 617.4 |
| SPRR2A | Small proline-rich protein 2A | 324.5 | |
| CSN2 | Casein beta | 174.7 | |
| SPRR2E (2×) | small proline-rich protein 2E | 109.7 to 163.2 | |
| LTF | Lactotransferrin | 121.9 | |
| S100A9 | S100 calcium binding protein A9 | 90.9 | |
| ASGR2 | asialoglycoprotein receptor 2 | 66.4 | |
| S100A12 | S100 calcium binding protein A12 | 66.3 | |
| Cluster 5# | APOBEC2 | Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2 | -4.6 |
| Unknown | N/A | -2.1 | |
| ZACN | Zinc activated ligand-gated ion channel | -2.0 | |
| HSPA8 | Heat shock 70 kDa protein 8 | -1.7 | |
| ADAMTS2 | ADAM metallopeptidase with thrombospondin type 1 motif, 2 | -1.7 | |
| FGL2 | Fibrinogen-like 2 | -1.6 | |
| Cluster 6 | SFRP4 | Secreted frizzled-related protein 4 | -5.0 |
| TXNIP (3×) | Thioredoxin interacting protein | -3.4 to -3.9 | |
| Unknown | N/A | -2.8 | |
| SERPINF1 | Serpin peptidase inhibitor, clade F, member 1 | -2.7 | |
| FZD2 (2×) | Frizzled homolog 2 | -2.6 to -2.7 | |
| C3 | Complement component 3 | -2.4 | |
| FCGBP | Fc fragment of IgG binding protein | -2.3 | |
| Cluster 7 | SDPR | Serum deprivation response | -19.7 |
| NOSTRIN | nitric oxide synthase trafficker | -6.6 | |
| FAM13C | Family with sequence similarity 13, member C | -5.8 | |
| CDKN1C | Cyclin-dependent kinase inhibitor 1C (p57, Kip2) | -5.8 | |
| Unknown | N/A | -5.6 | |
| LIX1L | Lix1 homolog (mouse)-like | -5.5 | |
| SCARA5 | Scavenger receptor class A, member 5 (putative) | -5.3 | |
| COL3A1 | collagen, type III, alpha 1 | -4.9 to -5.1 | |
| Cluster 8 | CYP2F1 | Cytochrome P450, family 2, subfamily F, polypeptide 1 | -29.2 |
| CAP2 | CAP, adenylate cyclase-associated protein, 2 | -28.5 | |
| LOR | Loricrin | -26.3 | |
| IGFBP1 | Insulin-like growth factor binding protein 1 | -23.4 | |
| STMN2 | Stathmin-like 2 | -12.9 | |
| GFRA2 | GDNF family receptor alpha 2 | -11.5 | |
| CYP2B | Cytochrome P450, family 2, subfamily B | -9.3 | |
| FLG | Filaggrin | -8.6 | |
| KRT1 | Keratin 1 | -7.0 | |
| FMO3 | Flavin containing monooxygenase 3 | -6.4 |
Key - *Fold change calculated relative to baseline samples (Time = 0), range given where 2 or more probes for a gene are present. #Cluster 5 contained only 6 genes