Table 4.
Top five canonical pathways associated with each gene cluster following infestation with P. ovis
| Temporal cluster* | Canonical Pathway | p-valueA |
|---|---|---|
| Cluster 1 | p38 MAPK signalling | 2.9E-05 |
| IL12 signalling and production in macrophages | 5.4E-05 | |
| IL10 signalling | 6.9E-05 | |
| Aryl hydrocarbon receptor signalling | 1.3E-04 | |
| PPAR signalling | 2.9E-04 | |
| Cluster 2 | IL10 signalling | 1.2E-10 |
| Production of nitric oxide and reactive oxygen species in macrophages | 1.0E-09 | |
| Dendritic cell maturation | 1.8E-09 | |
| TREM1 signalling | 1.8E-09 | |
| NF-kB signalling | 6.7E-09 | |
| Cluster 3 | T helper cell differentiation | 6.4E-08 |
| IL10 signalling | 3.7E-06 | |
| NF-kB signalling | 1.6E-05 | |
| Acute phase response signalling | 6.1E-05 | |
| TREM1 signalling | 2.4E-04 | |
| Cluster 4 | Interferon signalling | 1.3E-05 |
| Leukocyte extravasation signalling | 2.9E-05 | |
| Antigen presentation pathway | 3.9E-05 | |
| T helper cell differentiation | 1.7E-04 | |
| CD28 signalling in T helper cells | 1.9E-04 | |
| Cluster 6 | Complement system | 5.3E-12 |
| Role of pattern recognition receptors in recognition of bacteria and viruses | 2.9E-06 | |
| Acute phase response signalling | 8.7E-05 | |
| Role of macrophages, fibroblasts and endothelial cells in RA# | 1.0E-03 | |
| Wnt/beta-catenin signalling | 2.3E-02 | |
| Cluster 7 | Aryl hydrocarbon receptor signalling | 3.5E-03 |
| Antiproliferative role of somatostatin receptor 2 | 7.1E-03 | |
| CCR5 signalling in macrophages | 3.8E-02 | |
| Integrin signalling | 5.8E-02 | |
| IL1 signalling | 7.7E-02 | |
| Cluster 8 | Tight junction signalling | 2.4E-03 |
| BMP signalling pathway | 2.3E-02 | |
| TGF beta signalling | 2.8E-02 | |
| IL6 signalling | 3.8E-02 | |
| Wnt/beta-catenin signalling | 5.1E-02 |
Key - *Cluster 5 contained too few genes for effective analysis of canonical pathways. #Rheumatoid arthritis. Ap-value calculated using Fisher's exact test determining the probability that association between genes in the data set and canonical pathway is due to chance alone