Table 3.

Two way interactions without main-effect-SNPs. ORs and corresponding 95% confidence interval were estimated by the reduced model of unconditional logistic regression.

SNP-SNP interaction		OR	95% CI	P-Value*
SNP1	SNP2
OR < 1
rs4073674(DCTD)-AC	rs7632760(MLH1)-AG	0.74	(0.61,0.89)	1.24 × 10−3
rs12450989(TK1)-AA	rs6544990(MSH2)-AA	0.42	(0.24,0.73)	2.17 × 10−3
rs1980412(RRM1)-CC	rs7372736(MLH1)-GG	0.52	(0.34,0.80)	2.64 × 10−3
rs1980412(RRM1)-CC	rs9852810(MLH1)-TC	0.52	(0.34,0.80)	2.70 × 10−3
rs4073674(DCTD)-AC	rs6789043(MLH1)-TC	0.76	(0.63,0.91)	3.59 × 10−3
rs1980412(RRM1)-CC	rs7611106(MLH1)-AA	0.54	(0.35,0.82)	3.59 × 10−3
rs2854702(TK1)-AG	rs17036614(MSH2)-AG	0.51	(0.32,0.80)	3.67 × 10−3
rs1980412(RRM1)-CC	rs7632760(MLH1)-GG	0.55	(0.37,0.83)	3.89 × 10−3
rs1980412(RRM1)-CC	rs6789043(MLH1)-CC	0.56	(0.37,0.83)	3.90 × 10−3
rs2304891(RRM1)-TT	rs7372736(MLH1)-GG	0.52	(0.33,0.81)	4.16 × 10−3
OR > 1
rs2464974(DCTD)-GG	rs6544990(MSH2)-AA	1.77	(1.25,2.50)	1.26 × 10−3
rs7698606(DCTD)-TT	rs6544990(MSH2)-AA	1.85	(1.26,2.72)	1.66 × 10−3
rs7698606(DCTD)-TT	rs3771281(MSH2)-CC	1.81	(1.24,2.63)	2.04 × 10−3
rs6831306(DCTD)-CC	rs6544990(MSH2)-AA	2.25	(1.33,3.80)	2.53 × 10−3
rs6831306(DCTD)-CC	rs3771281(MSH2)-CC	2.12	(1.30,3.48)	2.82 × 10−3
rs2464974(DCTD)-GG	rs3771281(MSH2)-CC	1.62	(1.17,2.25)	3.56 × 10−3
rs7698606(DCTD)-TT	rs6544992(MSH2)-CC	1.59	(1.16,2.18)	3.65 × 10−3
rs2298582(TYMS)-AC	rs4952887(MSH2)-TC	1.93	(1.24,3.03)	3.72 × 10−3
rs7698606(DCTD)-TT	rs10188090(MSH2)-GG	1.74	(1.20,2.53)	3.74 × 10−3
rs7698606(DCTD)-TT	rs7584256(MSH2)-CC	1.57	(1.16,2.14)	3.91 × 10−3