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The time-course data during the behavioral sensitization phase. HIV-1Tg and F344 rats were administered nicotine (Nic; 0.35 mg/kg; s.c.) or saline (Sal) on Days 1–19. Panel A shows the total horizontal activity (mean ± S.E.M.) during the 30 min pre-injection habituation period. Panel B shows the total horizontal activity (mean ± S.E.M.) during the 60 min following nicotine or saline injection. n=8 rats per group.
