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. 2011 May 10;6(5):e14796. doi: 10.1371/journal.pone.0014796

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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Bifurcation diagrams of (A) and (B) with respect to the parameter according to the scaled version of system (2a)–(2b) (see Supplementary Material S1) at various levels of T-cell avidity ( and 0.9), are shown. As in Fig. 2, stable steady states are in solid lines and unstable steady states are in dashed lines. At high T-cell avidity, the range of bistability is large, but the decline in beta-cell number leads to a decrease in T-cell population size.

Inline graphic — Bifurcation diagrams of (A) and (B) with respect to the parameter according to the scaled version of system (2a)–(2b) (see Supplementary Material S1) at various levels of T-cell avidity ( and 0.9), are shown. As in Fig. 2, stable steady states are in solid lines and unstable steady states are in dashed lines. At high T-cell avidity, the range of bistability is large, but the decline in beta-cell number leads to a decrease in T-cell population size.