Figure 6. Scheme comparing T-cell avidity, killing efficacy and protein specificity of each subclone under consideration.
The vertical and horizontal axes correspond to the reciprocal of T-cell avidity (
) and T-cell killing efficacy (
), respectively. Auto-Ag
and Auto-Ag
are two islet-specific autoantigens. As shown, the two Auto-Ag
-reactive T-cell subclones (in their scaled form), t
and t
, are more avid and more efficacious in killing beta cells than the two Auto-Ag
-reactive T-cell subclones t
and t
(in their scaled form).