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. 2011 May 10;6(5):e14796. doi: 10.1371/journal.pone.0014796

Figure 11. Curve-fitting of T-cell response to autoantigenic stimulation with a given peptide (PPIInline graphic).

Figure 11

The percentage of CD8Inline graphic T cells (1E6 clone) staining for intracellular TNF-Inline graphic in response to (HLA-A2Inline graphic) PBMCs pulsed with varying concentrations of peptide was measured in [43] (black line). This dose-dependent behaviour was fitted to a Hill function (gray line) with a Hill coefficient of Inline graphic. The estimated value obtained for the level of peptide required for 50%-maximum T-cell activation was Inline graphic Inline graphicg/ml.