Table 2.

The RMSD and docking score from the docking simulation of 6 lowest configurations of co-crystal colchicine with tubulin (1SA0).

Configuration	Glide score	Δ Gscorea	RMSDb(Å)	RMSDc(Å)
1	−9.88	0	0.35	0.19
2	−8.94	0.94	0.45	0.24
3	−8.46	1.42	0.68	0.59
4	−8.23	1.65	0.33	0.76
5	−8.05	1.83	0.14	0.92
6	−7.64	2.24	0.82	1.06

^aΔG_score = E_i − E_lowest;

^bRMSD, RMSD between docked poses corresponding to each configuration;

^cRMSD, RMSD between docked and co-crystal colchicine structure (only heavy atoms from core rings are considered).