Figure 8.
Knockdown of Nogo-A prevented H-R-induced abnormal Ca2+ cycling. Quantitative comparison of Ca2+ transient amplitudes A), time to peak B), diastolic calcium C), and transient decay (tau) D) between NRVMs infected with Ad-shScr (open bars) or Ad-shN (closed bars) and subjected to normoxia or H-R. Data shown are the means ± SEM. *p < 0.05; **p<0.001; One-way ANOVA with Tukey’s post hoc analysis. E) Representative averaged calcium transients in NRVMs infected with shScr (solid line) or shN (dotted line) following H-R.