Table 1.

Genes up-regulated more than 4 fold in angiocidin-treated MB-231 cells as detected by PCR Array

Gene	Function	Fold Increase	Reference
TLR2	Immune cell receptor, promotes cytokine production through NFkB pathway, improve chemotherapy	34.3	(Garay et al., 2007)
IFNG	Immune cytokine, inhibits breast cancer proliferation	16	(Iacopino et al., 1997)
IFNB1	Immune cytokine, inhibits breast cancer proliferation	10.6	(Sica et al., 1987)
NR2C2/TR4	Orphan nuclear receptor	8	(Shyr et al., 2002)
PELI1	E3 ubiquitin ligase, promotes cytokine synthesis	7.5	(Chang et al., 2009)
REL	a member of the NFκB family of transcription factors.	6.5	(Biswas et al., 2004)
CD180	a member of the Toll-like receptors	6.1	(Aderem and Ulevitch, 2000)
MAPK8IP3	protein kinase, regulates the activity of numerous protein kinases of the JNK signaling pathway	5.3	(Davis, 2000)
CSF2/GM- CSF	Anti-tumorigenic cytokine in breast cancer	4.9	(Eubank et al., 2009)
MAP4K4	Protein kinase, upregulated p53 and drives c- Jun NH2-terminal kinase (JNK) Mediated apoptosis	4.0	(Miled et al., 2005)
IL1B	Inflammatory cytokine, promotes leukocyte differentiation, inhibits breast proliferation	4.0	(Roy et al., 2006)
c-FOS	Proto-oncogene important in breast cancer proliferation	4.0	(van der Burg et al., 1989)