Table 5.

Hazard ratios (95% confidence intervals) of dementia hospitalization by quartiles of FEV1, FVC and FEV1/FVC ratio at visit 2, ARIC, 1990–2005

FEV1	Q1	Q2	Q3	Q4	P for trend
N. cases	87	54	46	18
Person-years	29736	33288	34434	35765
Model 1	2.46 (1.44, 4.19)	1.79 (1.04, 3.09)	1.89 (1.09, 3.27)	1 (ref)	<0.0001
Model 2	1.59 (0.91, 2.78)	1.40 (0.81, 2.44)	1.68 (0.97, 2.92)	1 (ref)	0.03
Model 3	1.83 (0.71, 4.69)	1.95 (0.80, 4.72)	1.88 (0.78, 4.54)	1 (ref)	0.21
FVC	Q1	Q2	Q3	Q4	P for trend
N. cases	88	54	47	16
Person-years	30120	32861	33949	36294
Model 1	2.95 (1.68, 5.18)	2.22 (1.26, 3.92)	2.33 (1.32, 4.12)	1 (ref)	<0.0001
Model 2	2.08 (1.16, 3.72)	1.83 (1.03, 3.26)	2.09 (1.18, 3.70)	1 (ref)	0.006
Model 3	2.19 (0.82, 5.86)	1.99 (0.77, 5.12)	2.46 (0.97, 6.20)	1 (ref)	0.20
FEV1/FVC	Q1	Q2	Q3	Q4	P for trend
N. cases	60	44	47	54
Person-years	31850	33698	33904	33771
Model 1	1.06 (0.72, 1.56)	0.80 (0.53, 1.21)	0.93 (0.63, 1.38)	1 (ref)	0.07
Model 2	0.84 (0.55, 1.28)	0.78 (0.52, 1.19)	0.97 (0.65, 1.45)	1 (ref)	0.75
Model 3	1.09 (0.52, 2.30)	0.83 (0.41, 1.68)	1.60 (0.88, 2.90)	1 (ref)	0.56

Model 1: Cox proportional hazards model adjusted for age, gender, and race.

Model 2: As model 1, adjusted additionally for study center, cigarette smoking, pack-years of smoking, systolic blood pressure, body mass index, total cholesterol, HDL cholesterol, APOE genotype, use of hypertension medications, diabetes, use of lipid lowering medications, education, occupation, income and sports-related physical activity.

Model 3: As model 2, but restricted to non-smokers in visit 2