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. Author manuscript; available in PMC: 2012 May 10.
Published in final edited form as: J Am Chem Soc. 2011 Apr 14;133(18):6968–6977. doi: 10.1021/ja107052p

Figure 8.

Figure 8

Free energy curves for Co-C bond cleavage that depict the uncatalyzed thermolytic and native catalyzed thermolytic conditions, and representative trajectory of the cob(II)alamin-5′-deoxyadenosyl radical pair photoproduct, in EAL. The uncatalyzed thermolytic curve is based on calculated energy curves for Co-C bond cleavage for AdoCbl in solution and in proteins,42-44 and the native catalyzed thermolytic curve is based on the limit on the maximum of the free energy barrier of −15 kcal/mol.21 The representative photoproduct trajectory is based on calculations.41